Publications

Highlights

A summary of some published results on the Cancer Research UK website.

Gene variant related to greater difficulty in quitting smoking and earlier lung cancer diagnosis
CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis—a meta-analysis
Paper published in the Journal of the National Cancer Institute to which ReSuLuCENT contributed.

Science Spotlight feature on NIH National Institute of Drug Abuse & Addiction website.

Multi-centre collaboration

Cases and controls from ReSoLuCENT were included in a multi-centre collaboration through membership of the International Lung Cancer Consortium (ILCCO).

This has resulted in a number of recent high-profile publications, including the identification of 18 novel lung cancer genetic susceptibility variants, genetic differences between lung cancer subtypes and genetic interactions with smoking.

Plasma samples from ReSoLuCENT patients have been used to develop liquid biopsy-based tests for lung cancer.

2022

Rosenberger A, Muttray N, Hung RJ, Christiani DC, Caporaso NE, Liu G, et al. INTEGRAL-ILCCO Consortium. Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. Eur J Med Res. 2022 Jan 31;27(1):14.doi:https://doi.org/10.1186/s40001-022-00638-7. PMID: 35101137; PMCID: PMC8805279.

Schmid S, Jiang M, Brown MC, Fares A, Garcia M, Soriano J, et al. Accounting for EGFR mutations in epidemiological analyses of non-small cell lung cancers: Examples based on the International Lung Cancer Consortium data. Cancer Epidemiol Biomarkers Prev.
2022 Jan 13:cebp.0747.2021. doi:https://doi.org/10.1158/1055-9965.EPI-21-0747.

2021

Zhou W, Liu G, Hung RJ, Haycock PC, Aldrich MC, Andrew AS, et al. Causal relationships between body mass index, smoking and lung cancer: Univariable and multivariable Mendelian randomization. Int J Cancer. 2021 Mar 1;148(5):1077-1086. doi:https://doi.org/10.1002/ijc.33292.

Qin N, Li Y, Wang C, Zhu M, Dai J, Hong T, et al. Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma. Front Med 2021; 15: 275-291. doi: https://www.doi.org/10.1007/s11684-020-0779-4.

Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, et al. Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer. Genet Epidemiol 2021; 45: 99-114. doi: https://doi.org/10.1002/gepi.22358.

2020

Ji X, Mukherjee S, Landi MT, Bosse Y, Joubert P, Zhu D, et al. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun. 2020 May 11;11(1):2220. doi:https://doi.org/10.1038/s41467-020-15905-6.

Wang Y, Gorlova OY, Gorlov IP, Zhu M, Dai J, Albanes D, et al. Association analysis of driver-gene related genetic variants identified novel lung cancer susceptibility loci with 20,871 lung cancer cases and 15,971 controls. Cancer Epidemiol Biomarkers Prev 2020; 29: 1423-1429. doi: https://doi.org/10.1158/1055-9965.EPI-19-1085.

2019

Jiang X, Finucane H, Schumacher F, Schmit S, Tyrer J, Han Y, et al. Shared heritability and functional enrichment across six solid cancers. Nature Communications 2019; 10:431.doi:https://doi.org/10.1038/s41467-018-08054-4.

Zhu Y, Wei Y, Zhang R, Dong X, Shen S, Zhao Y, et al. Elevated platelet count appears to be causally associated with increased risk of lung cancer: A Mendelian randomization analysis. Cancer Epidemiol Biomarkers and Prevention 2019; 28:935–942. doi:https://doi.org/10.1158/1055-9965.EPI-18-0356.

Li Y, Xiao X, Bossé Y, Gorlova O, Gorlov I, Han Y, et al. Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development. Oncotarget 2019; 10: 1760–1774.doi:https://doi.org/10.18632/oncotarget.26678.

Dai J, Huang M, Amos CI, Hung RJ, Tardon A, Andrew A, et al. Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk. International Journal of Cancer 2019 Oct 2.doi:https://doi.org/10.1002/ijc.32698.

Bossé Y, Li Z, Xia J, Manem V, Carreras-Torres R, Gabriel A, et al. Transcriptome-wide association study reveals candidate causal genes for lung cancer. Int J Cancer 2019 Nov 6. doi: https://doi.org/10.1002/ijc.32771.

2018

Bossé Y, Li Z, Xia J, Manem V, Carreras-Torres R, Gabriel A, et al. Transcriptome-wide association study reveals candidate causal genes for lung cancer. International Journal of Cancer 2019 Nov 6.doi:https://doi.org/10.1002/ijc.32771.

Li Y, Xiao X, Han Y, Gorlova O, Qian D, Leighl N, et al. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population. Carcinogenesis 2018; 39: 336–346.

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D, et al. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nature Communications 2018; 9: 3221.doi:https://doi.org/10.1038/s41467-018-05074-y.

Ferreiro-Iglesias A, Lesseur C, McKay J, Hung R, Han Y, Zong X, et al. Fine-mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity. Nature Communications 2018; 9: 3927.doi:https://doi.org/10.1038/s41467-018-05890-2.uni

Carreras-Torres R, Johansson M, Haycock PC, Wade KH, Relton CL, Martin RM, et al. Obesity, metabolic factors and risk of different histological types of lung cancer: a Mendelian randomization study. PLOS ONE 2017; 12(6): e0177875.

2017

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, et al. Large scale genetic analysis identifies novel loci and histological variability in susceptibility to lung cancer. Nature Genetics 2017; 49: 1126–1132.

Wang T, Moon JY, Wu Y, Amos CI, Hung RJ, Tardon A, et al. Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium. PLoS One 2017; 12(9):e0185660.

2016

Chen L-S, Baker T, Hung RJ, Horton A, Culverhouse R, Hartz S, et al. Genetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes - a meta-analysis. EBioMedicine 2016; 11: 219–226.

Taylor F, Bradford J, Woll PJ, Teare D, Cox A. Unbiased detection of somatic copy number aberrations in cfDNA of lung cancer cases and high-risk controls with low coverage whole genome sequencing. Advances in Experimental Medicine and Biology 2016; 924: 29–32.

2015

Huang R, Wei Y, Hung RJ, Liu G, Su L, Zhang R, et al. Associated links among smoking, chronic obstructive pulmonary disease, and small cell lung cancer: a pooled analysis in the International Lung Cancer Consortium. EBioMedicine 2015; 2: 1677–1685.